NephrologyIntermediate

Furosemide Stress Test (FST for AKI Progression)

Evaluates 2-hour urinary response to loop diuretic challenge to predict progression to severe Stage 3 AKI and RRT.

Clinical Parameters

4 Variables

Awaiting Clinical Parameters

Configure the patient variables on the left and select Calculate Result to generate the clinical score and stratification.

Verified 2026 GuidelinesInstant Calculation
Jump to Formula & Clinical Protocol ↓
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Tested on Gulf Medical Boards (DHA, SMLE, MOH & HAAD)

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Clinical Significance & Diagnostic Standard
2026 Clinical Reference

What is the Furosemide Stress Test (FST for AKI Progression)?

📋Clinical Summary & Definition Capsule

The Furosemide Stress Test (FST for AKI Progression) is an evidence-based clinical decision rule engineered to quantify diagnostic probability, stratify clinical severity, and guide therapeutic decision-making in nephrology practice. Implements the Chawla Furosemide Stress Test (FST) protocol (1.0–1.5 mg/kg IV furosemide challenge in euvolemic patients with early AKI) using the 200 mL 2-hour urine threshold to stratify risk of dialysis and guide early nephrology consultation. Clinical scoring tools like Furosemide Stress Test (FST for AKI Progression) are essential in acute and outpatient management, enabling clinicians to objectively differentiate between low-risk candidates suitable for conservative therapy and high-risk patients requiring urgent interventions. Verified against current 2026 clinical standards, this tool is extensively tested on Gulf health authority licensing exams including DHA (Dubai), SMLE (Saudi Arabia), MOH, HAAD/DOH (Abu Dhabi), OMSB (Oman), and QCHP (Qatar).

💡Clinical Pearls & Diagnostic Utility

Provides a reliable functional dynamic assessment of renal reserve, identifying critically ill patients who will fail conservative management and require early dialytic intervention.

Mathematical Formulation

Formula & Calculation Parameters

The mathematical equation and clinical variables required to calculate Furosemide Stress Test (FST for AKI Progression):

FST Challenge: 1.0 mg/kg IV (diuretic naive) or 1.5 mg/kg IV (prior loop diuretic use).
Cutoff: 2-hour cumulative urine output < 200 mL indicates severe AKI progression risk (AUC-ROC 0.87).
Risk Stratification

Score Interpretation & Clinical Stratification

Score RangeClinical InterpretationRisk Tier
≤ 199Non-Responder (< 200 mL / High Risk of Stage 3 AKI & RRT)red
≥ 200FST Responder (≥ 200 mL / Preserved Tubular Function / Low Dialysis Risk)green
Clinical Limitations & Contraindications

When to Exercise Caution

Contraindicated in anuria, pre-existing Stage 5 CKD (baseline eGFR < 15), renal allograft, or acute volume depletion.

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Medical Review & Guidelines Compliance
MD

Clinical Review Board

Dr. Muhammad Nouman, MBBS

Capital Medical University | PMDC Reg No: 117744-P

Clinical Audit Status

✓ Verified for 2026 Guidelines

Last updated: 2026-08-08

Peer-Reviewed Medical Literature

  • Chawla LS, et al. Development and standardization of a furosemide stress test to predict the severity of acute kidney injury. Crit Care. 2013;17(5):R207.
  • Koyner JL, et al. Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity. J Am Soc Nephrol. 2015;26(8):2023-2031.
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