NephrologyBeginner

Fractional Excretion of Sodium (FeNa)

Differentiates prerenal disease from acute tubular necrosis (ATN).

Clinical Parameters

4 Variables
mEq/L
mg/dL
mEq/L
mg/dL

Awaiting Clinical Parameters

Configure the patient variables on the left and select Calculate Result to generate the clinical score and stratification.

Verified 2026 GuidelinesInstant Calculation
Jump to Formula & Clinical Protocol ↓
High Yield Prometric TopicNephrology

Tested on Gulf Medical Boards (DHA, SMLE, MOH & HAAD)

Clinical calculations and diagnostic scoring systems like Fractional Excretion of Sodium (FeNa) frequently appear on Prometric exams. Master high-yield clinical vignettes with instant AI-powered pathophysiology rationales.

Clinical Significance & Diagnostic Standard
2026 Clinical Reference

What is the Fractional Excretion of Sodium (FeNa)?

📋Clinical Summary & Definition Capsule

The Fractional Excretion of Sodium (FeNa) is an evidence-based clinical decision rule engineered to quantify diagnostic probability, stratify clinical severity, and guide therapeutic decision-making in nephrology practice. The Fractional Excretion of Sodium (FeNa) measures the percentage of filtered sodium that is excreted in the urine. It is widely used to evaluate acute kidney injury (AKI) to differentiate between prerenal states (where the kidneys hold onto sodium) and intrinsic renal disease like ATN (where the kidneys waste sodium). Clinical scoring tools like Fractional Excretion of Sodium (FeNa) are essential in acute and outpatient management, enabling clinicians to objectively differentiate between low-risk candidates suitable for conservative therapy and high-risk patients requiring urgent interventions. Verified against current 2026 clinical standards, this tool is extensively tested on Gulf health authority licensing exams including DHA (Dubai), SMLE (Saudi Arabia), MOH, HAAD/DOH (Abu Dhabi), OMSB (Oman), and QCHP (Qatar).

💡Clinical Pearls & Diagnostic Utility

A cornerstone diagnostic calculation in the workup of oliguric Acute Kidney Injury.

Mathematical Formulation

Formula & Calculation Parameters

The mathematical equation and clinical variables required to calculate Fractional Excretion of Sodium (FeNa):

FeNa (%) = (Urine Na × Serum Cr) / (Serum Na × Urine Cr) × 100
Risk Stratification

Score Interpretation & Clinical Stratification

Score RangeClinical InterpretationRisk Tier
≤ 1Prerenal Diseaseorange
1 – 2Indeterminateyellow
≥ 2Acute Tubular Necrosis (ATN)red
Clinical Limitations & Contraindications

When to Exercise Caution

Not accurate if the patient is taking diuretics (which artificially increase urine sodium). In such cases, the Fractional Excretion of Urea (FeUrea) is preferred.

Medical Review & Guidelines Compliance
MD

Clinical Review Board

Dr. Muhammad Nouman, MBBS

Capital Medical University | PMDC Reg No: 117744-P

Clinical Audit Status

✓ Verified for 2026 Guidelines

Last updated: 2026-08-07

Peer-Reviewed Medical Literature

  • Espinel CH. The FENa test. Use in the differential diagnosis of acute renal failure. JAMA. 1976;236(6):579-581.