Pharmacology

Vancomycin Pharmacokinetic Dosing & AUC/MIC Calculator

Calculates loading dose, maintenance regimen, and AUC24/MIC target for vancomycin.

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Parameters

Vancomycin Pharmacokinetic Dosing & AUC/MIC Calculator Result

Formula

Loading Dose = 20-35 mg/kg
Ke = (0.00083 × CrCl) + 0.0044
Vd = 0.7 L/kg
AUC₂₄ = Total Daily Dose / (Ke × Vd)

Clinical Pearls

Aligns vancomycin therapeutic drug monitoring with modern AUC/MIC pharmacokinetic targets, replacing non-specific high trough-only monitoring (15-20 mcg/mL) to reduce nephrotoxicity.

Limitations

Assumes stable renal function and MIC ≤ 1 mg/L; in acute renal instability or dialysis (HD/CRRT), Bayesian dosing software or serial level monitoring is mandatory.