Pharmacology
Anticholinergic Cognitive Burden (ACB) & AGS Beers Criteria® Risk
Calculates cumulative anticholinergic burden (ACB 0–9+) and flags high-risk potentially inappropriate medications in older adults.
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Parameters
Anticholinergic Cognitive Burden (ACB) & AGS Beers Criteria® Risk Result
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Formula
ACB Score = (Mild × 1) + (Moderate × 2) + (Severe × 3)
ACB ≥ 3 points indicates clinically significant risk of delirium, falls, cognitive impairment, and mortality.Clinical Pearls
Empowers clinicians and pharmacists to identify harmful cumulative polypharmacy and deprescribe anticholinergic medications to protect cognitive and physical function in seniors.
Limitations
Calculations should be paired with individualized clinical judgement regarding risk vs therapeutic benefit.