Pharmacology

Drug Elimination Half-Life & Steady-State Accumulation Calculator

Calculates elimination rate constant (ke), washout elimination percentage, time to steady state, and accumulation index.

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Parameters

Drug Elimination Half-Life & Steady-State Accumulation Calculator Result

Formula

ke = ln(2) / t1/2 = 0.693 / t1/2
C(t) = C0 × e^(-ke × t)
Accumulation Ratio (R) = 1 / (1 - e^(-ke × τ))

Clinical Pearls

Predicts the exact duration needed to achieve therapeutic steady state when initiating maintenance therapy and determines required pre-op drug washout windows.

Limitations

Calculations assume linear first-order elimination without auto-induction or active metabolites with prolonged independent half-lives.