Cardiology

Reynolds Risk Score (with hs-CRP)

Estimates 10-year cardiovascular risk incorporating high-sensitivity CRP and family history.

Parameters

years
mmHg
mg/L
mg/dL
mg/dL

Reynolds Risk Score (with hs-CRP) Result

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FormulaReynolds Risk Score = 1 - (S₀)^exp(B) B incorporates Age, ln(SBP), ln(hs-CRP), ln(Total Chol), ln(HDL), Smoking, and Parental MI < 60.

Clinical Pearls

Reclassifies up to 40-50% of intermediate-risk individuals into higher or lower clinical risk categories where treatment decisions become clear.

Limitations

hs-CRP must be measured in a stable baseline state; active acute infections, autoimmune flares, or trauma temporarily elevate CRP.