Hematology

Time in Therapeutic Range (TTR) & SAMe-TT₂R₂ Warfarin vs DOAC Score

Evaluates INR anticoagulation quality (Rosendaal TTR target ≥ 70%) and SAMe-TT₂R₂ score to guide DOAC transition.

Parameters

Time in Therapeutic Range (TTR) & SAMe-TT₂R₂ Warfarin vs DOAC Score Result

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FormulaSAMe-TT₂R₂ = Sex (F=1) + Age (<60=1) + Medical Comorbidities (≥2=1) + Treatment (Amiodarone=1) + Tobacco (2) + Race (Non-Caucasian=2) TTR ≥ 70% defines international gold-standard anticoagulation quality.

Clinical Pearls

Prevents preventable thromboembolic strokes and fatal hemorrhages by identifying patients failing vitamin K antagonist therapy who will benefit from modern DOACs.

Limitations

TTR requires at least 3 to 6 months of consecutive INR records to calculate reliably via linear interpolation.