Pharmacology

Weight-Based Heparin Infusion & Titration Protocol

Calculates initial weight-based IV heparin bolus, infusion rate, and dynamic aPTT / Anti-Xa titration nomograms.

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Parameters

Weight-Based Heparin Infusion & Titration Protocol Result

Formula

VTE Starting Dose: 80 units/kg Bolus + 18 units/kg/hr Infusion
ACS Starting Dose: 60 units/kg Bolus + 12 units/kg/hr Infusion
Titrated to Target aPTT (50-70 sec) or Anti-Xa (0.3-0.7 IU/mL)

Clinical Pearls

Achieves therapeutic anticoagulation rapidly within 24 hours, significantly reducing recurrent venous thromboembolism and ischemic complications.

Limitations

Use total body weight up to 130-150 kg; in severe morbid obesity (BMI > 40), consider capping bolus or pharmacy dosing consultation.