Pharmacology
Total Body Drug Clearance (CL = Dose / AUC = Ke × Vd) Calculator
Calculates systemic drug clearance (L/hr & mL/min), renal vs hepatic elimination, and steady-state maintenance rate.
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Parameters
Total Body Drug Clearance (CL = Dose / AUC = Ke × Vd) Calculator Result
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Formula
Systemic Clearance: CL = (F × Dose) / AUC₀-∞ = Ke × Vd
Renal Clearance: CLR = fe × CL (where fe = fraction excreted unchanged in urine)
Maintenance Infusion Rate: R₀ = CL × Target CssClinical Pearls
The core pharmacokinetic metric that bridges pharmacology and patient bedside care, ensuring therapeutic drug levels without toxicity.
Limitations
Assumes linear first-order elimination; non-linear (Michaelis-Menten) kinetics (e.g. Phenytoin, high-dose Aspirin, Alcohol) require capacity-limited Vmax/Km modeling.