Endocrinology

HOMA-IR

Estimates insulin resistance from fasting glucose and insulin.

Parameters

mg/dL
µU/mL (or mIU/L)

HOMA-IR Result

--
FormulaHOMA-IR = (Fasting Glucose [mg/dL] × Fasting Insulin [µU/mL]) / 405 (Note: If glucose is in mmol/L, divide by 22.5 instead)

Clinical Pearls

Provides a simple, cost-effective way to quantify insulin resistance in clinical practice and research, without needing a complex hyperinsulinemic-euglycemic clamp.

Limitations

Not validated for use in patients receiving exogenous insulin therapy. Assumes a steady state (fasting) and normal hepatic insulin extraction.