EndocrinologyBeginner

HOMA-IR

Estimates insulin resistance from fasting glucose and insulin.

Clinical Parameters

2 Variables
mg/dL
µU/mL (or mIU/L)

Awaiting Clinical Parameters

Configure the patient variables on the left and select Calculate Result to generate the clinical score and stratification.

Verified 2026 GuidelinesInstant Calculation
Jump to Formula & Clinical Protocol ↓
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High Yield Prometric TopicEndocrinology & Metabolism

Tested on Gulf Medical Boards (DHA, SMLE, MOH & HAAD)

Clinical calculations and diagnostic scoring systems like HOMA-IR frequently appear on Prometric exams. Master high-yield clinical vignettes with instant AI-powered pathophysiology rationales.

Clinical Significance & Diagnostic Standard
2026 Clinical Reference

What is the HOMA-IR?

📋Clinical Summary & Definition Capsule

The HOMA-IR is an evidence-based clinical decision rule engineered to quantify diagnostic probability, stratify clinical severity, and guide therapeutic decision-making in endocrinology & metabolism practice. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) is a widely used method for estimating insulin resistance. It is calculated from basal (fasting) glucose and insulin levels. Clinical scoring tools like HOMA-IR are essential in acute and outpatient management, enabling clinicians to objectively differentiate between low-risk candidates suitable for conservative therapy and high-risk patients requiring urgent interventions. Verified against current 2026 clinical standards, this tool is extensively tested on Gulf health authority licensing exams including DHA (Dubai), SMLE (Saudi Arabia), MOH, HAAD/DOH (Abu Dhabi), OMSB (Oman), and QCHP (Qatar).

💡Clinical Pearls & Diagnostic Utility

Provides a simple, cost-effective way to quantify insulin resistance in clinical practice and research, without needing a complex hyperinsulinemic-euglycemic clamp.

Mathematical Formulation

Formula & Calculation Parameters

The mathematical equation and clinical variables required to calculate HOMA-IR:

HOMA-IR = (Fasting Glucose [mg/dL] × Fasting Insulin [µU/mL]) / 405
(Note: If glucose is in mmol/L, divide by 22.5 instead)
Risk Stratification

Score Interpretation & Clinical Stratification

Score RangeClinical InterpretationRisk Tier
≤ 1.9Healthy (Insulin Sensitive)green
1.9 – 2.9Early Insulin Resistanceyellow
≥ 2.9Significant Insulin Resistancered
Clinical Limitations & Contraindications

When to Exercise Caution

Not validated for use in patients receiving exogenous insulin therapy. Assumes a steady state (fasting) and normal hepatic insulin extraction.

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Medical Review & Guidelines Compliance
MD

Clinical Review Board

Dr. Muhammad Nouman, MBBS

Capital Medical University | PMDC Reg No: 117744-P

Clinical Audit Status

✓ Verified for 2026 Guidelines

Last updated: 2026-08-07

Peer-Reviewed Medical Literature

  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419.
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